Welcome to Ora Biomedical, Inc.
Healthy aging therapies for next generation medicine
Ora Biomedical develops small molecule therapeutics that extend lifespan and delay chronic illness by targeting the underlying molecular mechanisms of aging.
See Matt Kaeberlein talk about the MMC!
The million-molecule challenge - a moonshot project to rapidly advance longevity intervention discovery
About Us
Preclinical discovery at our foundations
We set ourselves apart in longevity biotechnology by having the largest preclinical drug screening operation of its kind. This is possible with the WormBot-AI, an automated high-throughput robotics platform combined with state-of-the-art AI-based data analysis. By measuring health and survival in the small animal C. elegans, we can screen up to 144 populations in parallel with a single WormBot-AI. We use this powerful system to identify small molecule gerotherapeutics that modify normal aging and age-related disease pathology. Our team combines this innovative platform with decades of research excellence to provide best-in-class discovery science.
Our strategy
An evolutionary approach
Our Translational Geroscience approach identifies small molecules and natural products that target evolutionarily conserved aging mechanisms. Interventions targeting these mechanisms are screened across age-associated and rare disease models. Broad acting gerotherapeutics are then validated in mammalian studies on the path to clinical approval.
Small molecule and natural product analysis
High-throughput and unbiased compound screening to identify novel single and combination healthy aging interventions.
Normative aging and disease models
Therapeutics are selected by analyzing lifespan and healthspan measures, like age-associated movement and behavior changes. Suppression of disease phenotypes for age-associated and other rare diseases are also assessed.
Mechanistic and translational validation studies leading to clinical development
Drug targets are characterized using genetic, biochemical, and multi-omic approaches. Disease indications are identified using our disease mutant panel. Targets are validated for mammals from expression data studies across different animals. IND-enabling and other necessary studies are performed by us and our research partners to advance gerotherapeutics into clinical trials or other consumer markets.
Our Purpose
Developing the future of preventative medicine
Aging is the greatest predisposing factor to the chronic illnesses and diseases that limit quality lifespan and ultimately lead to death. Targeting the underlying mechanisms of aging using gerotherapeutics holds the promise to extend both maximal lifespan and increase the number of years spent in good health.
Ora Biomedical is excited to partner with both academic and commercial clients interested in evaluating novel therapies. Please contact us if you’re interested in Ora Biomedical accelerating your drug discovery and evaluation pipeline!Â